- The Effects of Diazepam on the Carbachol Induced Contraction of the Isolated Rat Ileum.
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Jung Ok Kim, Oh Cheol Kwon, Jeoung Hee Ha, Kwang Youn Lee, Won Joon Kim
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Yeungnam Univ J Med. 1989;6(2):13-22. Published online December 31, 1989
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DOI: https://doi.org/10.12701/yujm.1989.6.2.13
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 Abstract
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- To investigate the effect of diazepam on the contractility of the intestinal smooth muscle, longitudinal muscle strip isolated from rat ileum was prepared for myography in isolated organ bath. 1) Basal tone of ileal muscle was reduced by diazepam concentration-dependently. 2) Higher concentrations (30 and 100 microM) of diazepam inhibited (p<0.05, p<0.001) The carbachol-induced contraction in a concentration-dependent manner; but lower concentration of diazepam (10 microM) enhanced (p<0.05). 3) Histamine-induced contraction was inhibited by pretreatment with diazepam in a concentration-dependent manner. 4) Ca⁺⁺-induced tension recovery in calcium-free solution was inhibited in the presence of diazepam concentration-dependently. These results suggest diazepam reduces the contractility of the longitudinal muscle isolated from rat ileum via interference with influx of calcium into the muscle cells.
- A Clinical Study on Low Birth Weight Infants.
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Han Ku Moon, Jung Ok Kim, Jae Honng Park, Son Moon Shin, Jeong Ok Hah
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Yeungnam Univ J Med. 1987;4(2):97-103. Published online December 31, 1987
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DOI: https://doi.org/10.12701/yujm.1987.4.2.97
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Abstract
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- Neonatal and obstetrical problems related to the low birth weight infants were evaluated by a retrospective review of the medical records of the 186 low birth weight infants born at Yeungnam University Hospital during 3 years and 8 months from May 1, 1983 to February 28, 1987. The results were as follows: 1. The incidence of the low birth weight infants was 4.98% among 3,803 live births. 2. Male to female ratio was 1.02:1. 3. The incidence of the low birth weight infants was lowest in mothers of 25 to 29 years, increased in mothers of 19 years of less and 30 to 39 years significantly. 4. There was no difference in the incidence of low birth weight infants between primiparous and multiparous mothers. 5. Common obstetrical complications associated with low weight infants were multiple pregnancy, toxemia and premature rupture of membrane in order of frequency. 6. Common neonatal problems in low birth weight infants were jaundice, idiopathic respiratory, distress syndrome, asphyxia and metabolic derangement such as hypocalcemia and hypoglycemia in order of frequency.
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